North Queensland Toyota Cowboys coach Paul Green will go into the Panthers clash with the same side that scored the club's first win of the season last weekend.
It will be fullback Lachlan Coote's first outing against his old club and his third back in the NRL for the Cowboys.
The teams' last meeting was a Monday night game in round 23, 2014, which Penrith won in golden point 23-22 and ended the Cowboys' four-game winning streak.
Kick off is at 7pm.
COWBOYS: 1. Lachlan Coote 2. Matthew Wright 3. Tautau Moga 4. Kane Linnett 5. Antonio Winterstein 6. Michael Morgan 7. Johnathan Thurston (c) 8. Matthew Scott (c) 9. Jake Granville 10. James Tamou 11. Gavin Cooper 12. Ethan Lowe 13. Jason Taumalolo. Interchange: 14. Rory Kostjasyn 16. Scott Bolton 17. Ben Hannant 18. John Asiata.