Updated: Tuesday 24 August 2010
| Player | Squad | Position | Injury | Status |
| Willie Tonga | NRL | Centre | Groin | Season |
| Luke O'Donnell | NRL | Lock | Knee | TBA |
| Johnathan Thurston | NRL | Halfback | Ankle | Season |
| Steve Rapira | NRL | Back Row | Groin | Season |
| Steve Southern | NRL | Second Row | Knee | Season |
| Mitchell Achurch | NRL | Second Row | Knee | Season |
| | | | | |
| Michael Morgan | NYC | Five-eighth | Hand | TBA |
| Ray Thompson | NYC | Five-eighth | Shoulder | Season |
| Mitchell Zornig | NYC | Centre | ACL | Season |
| Dylan Smith | NYC | Second Row | ACL | Season |
| Kurtis Ritchie | NYC | Back Row | ACL | Season |
| | | | |
The release of information relating to players' injuries will be at the discretion of the North Queensland Toyota Cowboys.
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